Clicking on an item will open the viewer and discussion panel. Users can click on the Add a Comment button to add to the discussion (if allowed). Comments can also be marked as a question. If marked as a question, the comment will be placed in the Open tab, while normal comments will be automatically placed in Resolved.
Clicking on the Open tab will show all questions that haven't yet been resolved. Users can upvote comments, directly reply to them in a nested fashion, and if you're an Admin, mark them as resolved or delete them.
At the top of the page when viewing content, you'll find buttons to add the file to My Library for quick access in the future, minimize the discussion panel for a more immersive experience, and to close the item.